Next-Generation CAR-T: Targeted Nanoparticle Delivery Offers Scalable, Off-the-Shelf Solution

CAR-T Cell Therapy (Chimeric Antigen Receptor T cell therapy) is an advanced immunotherapy that involves reprogramming a patient’s own T cells to recognize and attack cancer or trouble cells. The T cells taken from the patient’s blood are engineered to express chimeric antigen receptors (CARs) on their surface. These CARs help the T cells recognize specific targets, like […]

Unraveling Norovirus: How the NS3 Translocase Powers Viral RNA Transport Across Membranes and Emerges as a Novel Antiviral Target

Recent studies reveal that NS3 functions as an RNA translocase, actively transporting RNA across cellular membranes. It achieves the movement by coupling ATP hydrolysis-providing the energy required for RNA transport. Across membrane invasion initiates the norovirus replication cycle including steps like RNA replication and the assembly of new viral particles. Targeting NS3 could interrupt the […]