Enzyme Evolution, Decoded by AlphaFold2
AlphaFold2 predicts protein structures with near-experimental accuracy, transforming the study of enzyme evolution across species. A recent study used AlphaFold2 to analyze metabolic enzymes from ancient to modern organisms, combining predicted and known structures to reveal how metabolism drives structural changes. Enzyme evolution is shaped by reaction mechanisms, metal interactions, metabolic flux, and biosynthetic costs. […]