A recent study published in Advanced Science reveals that circular RNA (circRNA) plays a vital role in skin wound healing, offering potential for new treatments aimed at enhancing recovery and minimizing scarring.

Scientists have identified a specific circRNA, called CircGLIS3(2), that becomes active in skin fibroblasts—the cells responsible for repairing damaged tissue—shortly after injury. The expression of CircGLIS3(2) is triggered by typical injury-related signals, including inflammation, low oxygen (hypoxia), and cellular stress. This discovery sheds light on the molecular processes behind tissue repair and opens the door to targeted therapies for improved wound healing outcomes.

More reading:

Guanglin Niu et al, Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair, Advanced Science (2025). DOI: 10.1002/advs.202416784