Bispecific antibodies (bsAbs) provide novel mechanisms of action and therapeutic possibilities beyond those achievable with conventional IgG-based antibodies. Their development has accelerated over the past decade, leading to the approval of 14 bsAbs by the end of 2023—11 for oncology indications and 3 for non-oncology uses. These molecules come in various formats, target a wide […]
This study in eLife highlights that YAP, a protein linked to cancer therapy resistance, behaves differently depending on how cancer cells are cultured. In non-small cell lung cancer (NSCLC) with EGFR or KRAS mutations, resistance to targeted therapies is common. The research shows that acute resistance to EGFR/KRAS/BRAF inhibition is highly dependent on spatial and […]
Leptomeningeal metastasis—a deadly spread of solid tumors to the cerebrospinal-fluid-filled membranes around the brain and spinal cord—is characterized by strong immune infiltration and high levels of interferon-gamma (IFNγ). Researchers developed mouse models of lung cancer, breast cancer, and melanoma with leptomeningeal metastasis and found that mice lacking IFNγ or its receptor couldn’t control tumor growth. […]
MinneBio proudly presents its highly anticipated “Workshop on Enzyme Engineering and Applications,” a comprehensive event designed to delve into the intricate world of enzyme technology. Enzymes, the molecular workhorses of life, play a pivotal role in various industries, from pharmaceuticals to renewable energy. This workshop serves as a platform for researchers, scientists, and industry professionals to explore the latest advancements, practical applications, and future prospects of enzyme engineering.
