Expanding the Therapeutic Frontier with Bispecific Antibodies

Bispecific antibodies (bsAbs) provide novel mechanisms of action and therapeutic possibilities beyond those achievable with conventional IgG-based antibodies. Their development has accelerated over the past decade, leading to the approval of 14 bsAbs by the end of 2023—11 for oncology indications and 3 for non-oncology uses. These molecules come in various formats, target a wide […]

YAP-Mediated Therapy Resistance in NSCLC Depends on Tumor Architecture

This study in eLife highlights that YAP, a protein linked to cancer therapy resistance, behaves differently depending on how cancer cells are cultured. In non-small cell lung cancer (NSCLC) with EGFR or KRAS mutations, resistance to targeted therapies is common. The research shows that acute resistance to EGFR/KRAS/BRAF inhibition is highly dependent on spatial and […]